15N标记的邻苯二甲酰亚胺的合成。

Synthesis of 15N-labeled phthalimide.

作者信息

Liu Zhanfeng, Yuan Qipeng

机构信息

College of Life Science and Technology, Beijing University of Chemical Technology, P.O. Box 75, Beijing, 100029, China.

出版信息

Appl Radiat Isot. 2006 Jul;64(7):760-2. doi: 10.1016/j.apradiso.2006.01.006. Epub 2006 Mar 3.

DOI:10.1016/j.apradiso.2006.01.006

PMID:16516481

Abstract

A new method for preparing 15N-labeled phthalimide from the reaction between phthalic anhydride and 15N-urea (99.34% 15N) in the presence of ortho-xylene is described in this work. Reaction conditions were the mole ratio of phthalic anhydride to 15N-urea (99.34% 15N) of 3-1 at 140 degrees C and under atmospheric pressure. Excessive phthalic anhydride reacted with ethanol for 90 min. The by-product of diethyl phthalate dissolving in ethanol was separated by filtration. The high yield of 96% of 15N-labeled phthalimide was obtained and the purity and abundance was 99.5% and 99.04%, respectively.

摘要

本文描述了一种在邻二甲苯存在下，由邻苯二甲酸酐与15N-尿素（15N含量99.34%）反应制备15N标记邻苯二甲酰亚胺的新方法。反应条件为邻苯二甲酸酐与15N-尿素（15N含量99.34%）的摩尔比为3:1，反应温度140℃，常压。过量的邻苯二甲酸酐与乙醇反应90分钟。通过过滤分离溶解在乙醇中的副产物邻苯二甲酸二乙酯。获得了产率高达96%的15N标记邻苯二甲酰亚胺，其纯度和丰度分别为99.5%和99.04%。