Zissen Maurice H, Zhang Guohua, Kendig Joan J, Sweitzer Sarah M
Department of Anesthesiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Neurosci Lett. 2006 May 29;400(1-2):154-7. doi: 10.1016/j.neulet.2006.02.039. Epub 2006 Mar 6.
The present study tested the hypothesis that morphine exposure during the human developmental equivalent of the third trimester would alter inflammatory pain. This study examined whether acute or continuous opioid exposure in the neonatal rat alters formalin-induced nociception after 4 days of abstinence. Rats were exposed to a single acute administration of morphine on postnatal day 7 or 72 h of opioid infusion from postnatal days 5-7 via osmotic pump. When challenged with intraplantar formalin on postnatal day 11, rats exposed to acute or chronic morphine had increased phase II pain-associated behaviors. These findings suggest that neonatal morphine exposure may have unintended consequences on inflammatory pain.
在人类发育相当于孕晚期的阶段接触吗啡会改变炎性疼痛。本研究考察了新生大鼠急性或持续接触阿片类药物后，在戒断4天后是否会改变福尔马林诱导的伤害感受。大鼠在出生后第7天接受单次急性吗啡给药，或从出生后第5 - 7天通过渗透泵进行72小时的阿片类药物输注。在出生后第11天接受足底注射福尔马林刺激时，急性或慢性接触吗啡的大鼠与疼痛相关的II期行为增加。这些发现表明，新生大鼠接触吗啡可能会对炎性疼痛产生意想不到的后果。
