Young Kevin D
Trends Microbiol. 2006 Apr;14(4):155-6. doi: 10.1016/j.tim.2006.02.004. Epub 2006 Mar 6.
In a recent Opinion article in Trends in Microbiology, Dmitriev et al. proposed an alternative to the existing model of peptidoglycan structure, in which the cell wall is composed of chains that are perpendicular to the membrane (as opposed to horizontal) and form a scaffold interconnected by peptide branches. However, both this model and the classical model are based on underlying assumptions about pore sizes, composition and structural regularity that deserve careful consideration. Not only do the uncertainties surrounding these basic mechanical questions make it impossible to decide which model of peptidoglycan structure is correct, they also leave open the possibility that the real structure is an amalgam of these or other models that have yet to be described.
在《微生物学趋势》最近的一篇观点文章中，德米特里耶夫等人提出了一种替代现有肽聚糖结构模型的方案，在该模型中，细胞壁由垂直于细胞膜（而非水平方向）的链组成，并形成一个由肽分支相互连接的支架。然而，这一模型和经典模型都基于关于孔径、组成和结构规则性的潜在假设，这些假设值得仔细考量。围绕这些基本力学问题的不确定性不仅使得无法确定哪种肽聚糖结构模型是正确的，还留下了一种可能性，即真实结构是这些模型或其他尚未描述的模型的混合体。
