[一组八十岁以上老人甲状腺功能的评估]

[Evaluation of thyroid function in a group of over-eighty year-old people].

作者信息

Ruotolo G, Dattilo B, Gareri P, La Cava R, Talarico F, De Nardo F, Galasso S, Tancrè D, Galasso D

机构信息

Seconda Divisione di Medicina Interna, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro.

出版信息

Minerva Med. 2005 Dec;96(6):391-5.

PMID:16518301

Abstract

AIM

A number of studies has shown that during aging thyroid presents some structural changes, whilst no data agree about secretory activity. The aim of the present study was to evaluate thyroid function in a group of healthy over-80 years old people vs a group of young subjects.

METHODS

This study was performed on 48 old people, 33 women (68.75%) and 15 men (31.25%), mean age 86.38+/-5.20 years old and 43 young subjects, mean age 33.35+/-3.75 years old; all of them were euthyroid and were not affected with any acute or chronic diseases and did not take any drugs which could interfere with thyroid function. A blood sample was taken from each patient, for dosing TT3, TT4, FT3, FT4, TSH, TgAb, TPOAb.

RESULTS

The results of the present study show low serum levels of TT3 in healthy over-80 year old people compared to young people, even if serum levels of TT4, FT3, FT4, TSH have no significant changes.

CONCLUSIONS

Functional reduction in thyroid activity during aging has not to be considered responsible for senile involution; it is more appropriate to define it as the expression of a metabolic slow down in the elderly.

摘要

目的

多项研究表明，在衰老过程中甲状腺会出现一些结构变化，而关于其分泌活性的数据尚无定论。本研究的目的是评估一组80岁以上健康人群与一组年轻受试者的甲状腺功能。

方法

本研究对48名老年人进行，其中33名女性（68.75%）和15名男性（31.25%），平均年龄86.38±5.20岁，以及43名年轻受试者，平均年龄33.35±3.75岁；他们均甲状腺功能正常，未患任何急慢性疾病，且未服用任何可能干扰甲状腺功能的药物。从每位患者采集血样，用于测定TT3、TT4、FT3、FT4、TSH、TgAb、TPOAb。