甘肃省武威市城区成年人碘营养与甲状腺功能分析

[Analysis of iodine nutrition and thyroid function of adults in urban areas of Wuwei city Gansu province].

作者信息

Dou Yugui, Wang Yanling, Wang Tingcai, Liang Liping, Ren Xudong, Li Hongbo, Zhu Xiaonan

机构信息

Gansu Center for Disease Prevention and Control, Lanzhou 730020, China.

出版信息

Wei Sheng Yan Jiu. 2014 Jan;43(1):58-62.

PMID:24564112

Abstract

OBJECTIVE

To find out the iodine nutrition and thyroid function of adults in urban areas of Wuwei city Gansu province and to provide a basis for scientific iodine supplementation.

METHODS

A cross-sectional survey was performed in 104 adults in Wuwei city form the April 2009 to January 2010. The morning blood samples and one urine samples selected randomly of different people were collected and three free triiodothyronine (FT3), free thyroid hormone (FT4), total triiodothyronine (TT3), total thyroxine (TT4), the thyroid-stimulating hormone (TSH), thyroglobulin antibodies (TGAb), thyroid microsomal antibodies (TMAb) in blood samples and iodine in urine samples were detected.

RESULTS

The medians of urinary iodine were respectively 139.3 microg/L and 212.6 microg/L for male and female, female was significantly higher than male, there were statisticant differences (P < 0.05). TT3, TT4, FT4, FT3 and TSH's mean values were in the normal range, the abnormal ratio of TT3, TT4, FT3, FT4, TSH were respectively 1.9%, 1.0%, 3.8%, 1.9%, 16.3%. The positive rate of TGAb and TMAb in female were all higher than male, there were statisticant differences (P < 0.05). Subclinical hypothyroidism in all thyroid function disorders was most and accounted for 14.4% and female were all higher than male (P < 0.05). The survey were divided into iodine deficiency group, adequate iodine group, over adequate iodine group and iodine excess group for urinary iodine level. The abnormal ratio of TT3, TT4, FT3, FT4, TSH in four groups had no statistically differences, but the positive rate of TGAb and TMAb raised with increased urinary iodine level. Thyroid function disorders occurred in the other three groups except iodine deficiency group, and there were statisticant differences.

CONCLUSION

Iodine nutrition level is appropriate for adults in urban areas, but the female was higher than male. Subclinical hypothyroidism in all thyroid function disorders was most, the positive rate of TGAb and TMAb raised with increased urinary iodine level, the risk of female suffered from thyroid disease was higher than male.

摘要

目的

了解甘肃省武威市城区成年人碘营养及甲状腺功能状况，为科学补碘提供依据。

方法

于2009年4月至2010年1月对武威市104名成年人进行横断面调查。采集不同人群的清晨血样及随机选取的一份尿样，检测血样中的游离三碘甲状腺原氨酸（FT3）、游离甲状腺激素（FT4）、总三碘甲状腺原氨酸（TT3）、总甲状腺素（TT4）、促甲状腺激素（TSH）、甲状腺球蛋白抗体（TGAb）、甲状腺微粒体抗体（TMAb）以及尿样中的碘。

结果

男性尿碘中位数为139.3μg/L，女性为212.6μg/L，女性显著高于男性，差异有统计学意义（P<0.05）。TT3、TT4、FT4、FT3及TSH均值均在正常范围，TT3、TT4、FT3、FT4、TSH异常率分别为1.9%、1.0%、3.8%、1.9%、16.3%。女性TGAb和TMAb阳性率均高于男性，差异有统计学意义（P<0.05）。所有甲状腺功能异常中，亚临床甲减最多，占14.4%，女性高于男性（P<0.05）。根据尿碘水平将调查对象分为碘缺乏组、碘充足组、碘超足量组和碘过量组。四组中TT3、TT4、FT3、FT4、TSH异常率无统计学差异，但TGAb和TMAb阳性率随尿碘水平升高而升高。除碘缺乏组外，其他三组均出现甲状腺功能异常，差异有统计学意义。