[The value of determination of urine cAMP and cGMP in the diagnosis and predicting the therapeutic effect of malignant ovarian tumors].

Urine contents of cyclic adenosine 3', 5' monophosphate (cAMP) and cyclic guanosine 3', 5' monophosphate (cGMP) were determined by radio-immunoassay in 150 patients. Fourty patients had malignant ovarian tumor (study group), 20 had other malignant tumors (control group 1), 40 benign tumors (control group 2) and 50 had no tumors whatever (normal control group). Urine content of cAMP was lower cGMP was higher in the study group than the other groups. Following effective treatment, the urine contact of cAMP and the ratio of cGMP/cAMP returned normal. The results indicate that determinations of cGMP and cAMP as well as their ratio are useful for diagnosis and predicting the therapeutic effect in malignant ovarian tumors.