Plet Julien R H, Porter Michael J
Department of Chemistry, University College London, Christopher Ingold Building, 20 Gordon Street, London, UKWC1H 0AJ.
Chem Commun (Camb). 2006 Mar 21(11):1197-9. doi: 10.1039/b600819d. Epub 2006 Feb 14.
A synthesis of the 9-oxa-3-thiabicyclo[3.3.1]nonane ring system, which constitutes the core of the RNA polymerase inhibitor tagetitoxin, has been achieved through cyclisation of a thiol onto an electrophilic ketone.
9-氧杂-3-硫杂双环[3.3.1]壬烷环系是RNA聚合酶抑制剂万寿菊毒素的核心结构，该环系已通过硫醇与亲电酮的环化反应合成。
