Tsunetsugu-Yokota Yasuko, Ohnishi Kazuo, Takemori Toshitada
Department of Immunology, National Institute of Infectious Diseases, Toyama-cho, Shinjuku-ku, Tokyo, Japan.
Rev Med Virol. 2006 Mar-Apr;16(2):117-31. doi: 10.1002/rmv.492.
SARS-CoV is a new type of human coronavirus identified as a causative agent of severe acute respiratory syndrome (SARS). On the occasion of the SARS outbreak, various monoclonal antibodies (mAbs) against SARS-CoV have been developed and applied for diagnosis, clinical management and basic research. In this review, we overview the biochemical and functional properties and applications of these SARS-CoV mAbs. We also focus on a variety of vaccines currently under development and discuss the immune response elicited by these vaccines in animal models, hopefully to better understand what we need to do next to fight against newly emerging pathogens in the future.
严重急性呼吸综合征冠状病毒(SARS-CoV)是一种新型人类冠状病毒,被确定为严重急性呼吸综合征(SARS)的病原体。在SARS爆发之际,已开发出多种针对SARS-CoV的单克隆抗体(mAb),并将其应用于诊断、临床管理和基础研究。在本综述中,我们概述了这些SARS-CoV单克隆抗体的生化和功能特性及应用。我们还重点关注了目前正在研发的多种疫苗,并讨论了这些疫苗在动物模型中引发的免疫反应,希望能更好地理解我们未来对抗新出现病原体接下来需要做些什么。