Spoulou Vana I, Tsoumas Dimitris L, Ladis Vasilis, Spentzou Ageliki, Theodoridou Maria C
1st Department of Paediatrics, Division of Infectious Diseases, Aghia Sophia Children's Hospital, Athens University School of Medicine, Athens, Greece.
Vaccine. 2006 Apr 12;24(16):3050-3. doi: 10.1016/j.vaccine.2006.01.034. Epub 2006 Jan 30.
Natural and vaccine-induced immunity and immunological memory to Haemophilus influenzae type b (Hib) were evaluated in adolescents and adults with beta-thalassemia. At baseline 10/23 (43%) unvaccinated patients had naturally acquired anticapsular antibodies >0.15 microg/ml, the threshold of protection, compared to 9/10 (90%) aged-matched controls. Hib-conjugate vaccine (PRP-T) induced protective immune responses in all subjects and there were no differences in geometric mean concentrations at 1 month (GMC) between patients and controls (69.04 versus 40.5, respectively). Vaccine-induced immunological memory was assessed in 12 subjects with beta-thalassemia who had been vaccinated against Hib in the past. All subjects had retained PRP>1 microg/ml at baseline; PRP-T revaccination induced anamnestic responses which were similar, in terms of post vaccination antibody concentration (P=0.54) and avidity (P=0.08), with primary responses given by previously unvaccinated patients. A single dose of PRP-T induces adequate and long-lasting immunity and should be given in all unvaccinated adolescents and adults with beta-thalassemia.
对患有β地中海贫血的青少年和成年人的b型流感嗜血杆菌（Hib）自然免疫、疫苗诱导免疫及免疫记忆进行了评估。基线时，10/23（43%）未接种疫苗的患者自然获得了>0.15μg/ml的抗荚膜抗体（保护阈值），而年龄匹配的对照组中这一比例为9/10（90%）。Hib结合疫苗（PRP-T）在所有受试者中均诱导出了保护性免疫反应，患者和对照组在1个月时的几何平均浓度（GMC）无差异（分别为69.04和40.5）。对12名既往接种过Hib疫苗的β地中海贫血患者评估了疫苗诱导的免疫记忆。所有受试者在基线时PRP均>1μg/ml；PRP-T再接种诱导了回忆反应，在接种后抗体浓度（P=0.54）和亲和力（P=0.08）方面，与既往未接种疫苗患者的初次反应相似。单剂量PRP-T可诱导充分且持久的免疫力，应给予所有未接种疫苗的β地中海贫血青少年和成年人。
