2'-脱氧-4'-硫代嘧啶核苷的合成及生物活性
Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides.
作者信息
Secrist J A, Tiwari K N, Riordan J M, Montgomery J A
机构信息
Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35255-5305.
出版信息
J Med Chem. 1991 Aug;34(8):2361-6. doi: 10.1021/jm00112a007.
PMID:1652015
Abstract
2'-Deoxy-4'-thiocytidine (7 beta), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro. All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also active against herpes simplex 1 and human cytomegalovirus in cell culture.
摘要
已合成了2'-脱氧-4'-硫代胞苷（7β）、2'-脱氧-4'-硫代尿苷（9）和4'-硫代胸苷（10），并对其体外细胞毒性进行了评估。所有这些化合物对L1210、H-Ep-2和CCRF-CEM细胞系均具有细胞毒性。4'-硫代胸苷在细胞培养中对单纯疱疹病毒1型和人巨细胞病毒也有活性。
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