Kim Hong Yeon, Yoon Hae Sang
Department of Nursing, Gil Medical Center, Korea.
Taehan Kanho Hakhoe Chi. 2006 Feb;36(1):114-26. doi: 10.4040/jkan.2006.36.1.114.
This study was performed to evaluate the pre-emptive analgesic effects of a small dose of intravenous ketamine on postoperative pain in patients undergoing a hysterectomy.
Sixty patients undergoing a hysterectomy under general anesthesia were randomly allocated to 2 groups. The experimental group(30 patients) received 0.3 mg/kg of ketamine after induction of anesthesia, approximately 5 min prior to surgery, but the control group(30 patients) did not receive ketamine. Data was collected in a double-blind manner from April 1st, to October 30th, 2004. Postoperatively, the patients used a patient-controlled analgesia(PCA) pump. Blood pressure, pulse rate, pain, anxiety, count of times pressing the PCA button, administration of additional analgesics and side effects of ketamine were measured at 1 hour, 3 hours, 6 hours and 24 hours after the operation.
There were no statistical differences in blood pressure, pulse rate, pain and anxiety between the experimental and control groups. There were statistical differences in blood pressure, pulse rate, pain and anxiety during the 24 hours postoperatively. In the experimental group, the number of times pressing the PCA button and administering additional analgesic drugs were significantly lower than those of the control group.
A 0.3 mg/kg dose of ketamine given at approximately 5 min before surgery resulted in decreasing the number of times pressing the PCA and the administration of additional analgesics.
本研究旨在评估小剂量静脉注射氯胺酮对子宫切除术后患者疼痛的超前镇痛效果。
60例接受全身麻醉下子宫切除术的患者被随机分为2组。实验组（30例患者）在麻醉诱导后、手术前约5分钟接受0.3mg/kg氯胺酮，而对照组（30例患者）未接受氯胺酮。于2004年4月1日至10月30日以双盲方式收集数据。术后患者使用患者自控镇痛（PCA）泵。在术后1小时、3小时、6小时和24小时测量血压、脉搏率、疼痛、焦虑、按压PCA按钮的次数、额外镇痛药的使用情况以及氯胺酮的副作用。
实验组和对照组在血压、脉搏率、疼痛和焦虑方面无统计学差异。术后24小时内血压、脉搏率、疼痛和焦虑存在统计学差异。实验组按压PCA按钮的次数和使用额外镇痛药的次数明显低于对照组。
手术前约5分钟给予0.3mg/kg氯胺酮可减少按压PCA的次数和额外镇痛药的使用。
