奥美拉唑维持治疗可预防十二指肠溃疡手术后溃疡复发出血。
Omeprazole maintenance therapy prevents recurrent ulcer bleeding after surgery for duodenal ulcer.
作者信息
Demertzis Konstantinos, Polymeros Dimitrios, Emmanuel Theodoros, Triantafyllou Konstantinos, Tassios Pericles, Ladas Spiros D
机构信息
Hepatogastroenterology Unit, 2nd Department of Internal Medicine, Attikon University General Hospital, 23 Sisini Street, 11528 Athens, Greece.
出版信息
World J Gastroenterol. 2006 Feb 7;12(5):791-5. doi: 10.3748/wjg.v12.i5.791.
AIM
To evaluate the omeprazole maintenance therapy in patients with recurrent ulcer bleeding after surgery for duodenal ulcer.
METHODS
We studied 15 consecutive patients with recurrent ulcer bleeding after surgery for duodenal ulcer. Omeprazole (20 mg/d) maintenance therapy was given after ulcer healing. In addition to clinical follow-up, ambulatory 24-h gastric pH assay was performed before and during omeprazole therapy in those patients and controls with previous duodenal ulcer surgery but no ulcer recurrence.
RESULTS
All the 15 ulcers were healed after being treated with omeprazole (40 mg/d) for 2 mo. Eleven patients with two (1-9) episodes of recurrent ulcer bleeding completed the follow-up (43, 12-72 mo). None of them had a bleeding episode while on omeprazole. One patient discontinued the therapy and had recurrent bleeding. The median 24-h fraction time of gastric pH<4 in patients was 80, 46-95%, and was reduced to 32, 13-70% by omeprazole (P=0.002).
CONCLUSION
Long-term maintenance therapy with omeprazole (20 mg/day) is effective in preventing recurrent ulcer bleeding.
目的
评估奥美拉唑对十二指肠溃疡手术后复发性溃疡出血患者的维持治疗效果。
方法
我们研究了15例十二指肠溃疡手术后复发性溃疡出血的连续患者。溃疡愈合后给予奥美拉唑（20毫克/天）维持治疗。除临床随访外，对这些患者以及既往有十二指肠溃疡手术史但无溃疡复发的对照组患者，在奥美拉唑治疗前及治疗期间进行动态24小时胃pH值检测。
结果
15例溃疡经奥美拉唑（40毫克/天）治疗2个月后均愈合。11例有2次（1 - 9次）复发性溃疡出血发作的患者完成了随访（43、12 - 72个月）。他们在服用奥美拉唑期间均未出现出血发作。1例患者停止治疗后出现复发性出血。患者胃pH值<4的24小时平均时间百分比为80%（46 - 95%），奥美拉唑治疗后降至32%（13 - 70%）（P = 0.002）。
结论
奥美拉唑（20毫克/天）长期维持治疗可有效预防复发性溃疡出血。
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