人工病毒：一种用于基因递送的纳米技术方法。

Artificial viruses: a nanotechnological approach to gene delivery.

作者信息

Mastrobattista Enrico, van der Aa Marieke A E M, Hennink Wim E, Crommelin Daan J A

机构信息

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands.

出版信息

Nat Rev Drug Discov. 2006 Feb;5(2):115-21. doi: 10.1038/nrd1960.

DOI:10.1038/nrd1960

PMID:16521330

Abstract

Nanotechnology is a rapidly expanding multidisciplinary field in which highly sophisticated nanoscale devices are constructed from atoms, molecules or (macro)molecular assemblies. In the field of gene medicine, systems for delivering nucleic acids are being developed that incorporate virus-like functions in a single nanoparticle. Although their development is still in its infancy, it is expected that such artificial viruses will have a great impact on the advancements of gene therapeutics.

摘要

纳米技术是一个迅速发展的多学科领域，在这个领域中，高度精密的纳米级装置是由原子、分子或（宏观）分子组装体构建而成的。在基因医学领域，正在研发将病毒样功能整合到单个纳米颗粒中的核酸递送系统。尽管它们的发展仍处于起步阶段，但预计这种人工病毒将对基因治疗的进展产生重大影响。