Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Chem Soc Rev. 2012 Apr 7;41(7):2562-74. doi: 10.1039/c1cs15258k. Epub 2011 Nov 21.
Polymeric materials have been extensively developed as a delivery vehicle for nucleic acids over the past two decades. Many previous studies have demonstrated that synthetic delivery vehicles can be highly functionalized by chemical approaches to overcome biological barriers in nucleic acid delivery, similar to viruses. Based on our current knowledge, this tutorial review describes rational strategies in the design of polymeric materials to achieve construction of the versatile vehicles, that is "artificial viruses", for successful gene therapy, especially focusing on the chemical structures with the minimal adverse effects.
在过去的二十年中，高分子材料作为核酸的递药载体得到了广泛的发展。许多先前的研究表明，通过化学方法对合成递药载体进行高度功能化，可以克服核酸递药中的生物学屏障，类似于病毒。基于我们目前的知识，本综述描述了设计高分子材料的合理策略，以构建多功能载体，即“人工病毒”，用于成功的基因治疗，特别是侧重于具有最小不良反应的化学结构。
