日本血吸虫非融合型谷胱甘肽S-转移酶与谷胱甘肽复合物的晶体结构
Crystal structure of non-fused glutathione S-transferase from Schistosoma japonicum in complex with glutathione.
作者信息
Kursula I, Heape A M, Kursula P
机构信息
Department of Biochemistry, Biocenter Oulu, Oulu University, Oulu, Finland.
出版信息
Protein Pept Lett. 2005 Oct;12(7):709-12. doi: 10.2174/0929866054696154.
PMID:16522189
Abstract
Schistosoma japonicum glutathione S-transferase (SjGST) is a common fusion tag in recombinant protein production, and its 3-dimensional structure has been studied in the context of drug design. We have determined the crystal structure of non-fused SjGST complexed with glutathione, and compare it to complexes between glutathione and SjGST fusion proteins.
摘要
日本血吸虫谷胱甘肽S-转移酶（SjGST）是重组蛋白生产中常用的融合标签，并且其三维结构已在药物设计背景下进行了研究。我们确定了与谷胱甘肽复合的未融合SjGST的晶体结构，并将其与谷胱甘肽和SjGST融合蛋白之间的复合物进行比较。
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