Nagabuchi E, Une Y, Nakajima Y, Matsuoka S, Kamiyama T, Gotoda A, Saito M, Nagasako Y, Uchino J
First Dept. of Surgery, Hokkaido University School of Medicine.
Gan To Kagaku Ryoho. 1991 Aug;18(11):1837-41.
The effect of postoperative arterial infusion therapy using implanted reservoir was evaluated in 28 cases of resected hepatocellular carcinoma which showed at least one of those findings as Vp (+), Vv (+), IM (+) and more than 5 cm in tumor diameter. Ten of them underwent arterial infusion therapy with combination ADM and CDDP after hepatic resection (IA group) and the rest underwent no regional chemotherapy (control group). The one-, two- and three-year cumulative disease-free survival rates between control group and IA group were 55.6% against 80.0%, 25.4% against 70.0%, and 16.9% against 37.3%, respectively. The one-, two- and three-year cumulative survival rates between control group and IA group were 71.8% against 90.0%, 51.8% against 70.0% and 41.5% against 56.0%, respectively, a difference that was not statistically significant. We suggest this therapy can prevent intrahepatic recurrence, although it does not improve prognosis. To achieve a better prognosis, a new arterial infusion chemotherapy more effective than this one must be developed.
对28例已切除的肝细胞癌患者进行了评估，这些患者具有以下至少一项表现：Vp（+）、Vv（+）、IM（+）且肿瘤直径大于5 cm，研究了使用植入式储液器进行术后动脉灌注治疗的效果。其中10例在肝切除术后接受了阿霉素（ADM）和顺铂（CDDP）联合动脉灌注治疗（IA组），其余患者未接受区域化疗（对照组）。对照组和IA组的1年、2年和3年累积无病生存率分别为55.6%对80.0%、25.4%对70.0%、16.9%对37.3%。对照组和IA组的1年、2年和3年累积生存率分别为71.8%对90.0%、51.8%对70.0%、41.5%对56.0%，差异无统计学意义。我们认为这种治疗方法可以预防肝内复发，尽管它不能改善预后。为了获得更好的预后，必须开发一种比这种方法更有效的新型动脉灌注化疗方法。
