[细菌性或病毒性脑膜炎患儿的血清降钙素原水平]

[Serum procalcitonin levels in children with bacterial or viral meningitis].

作者信息

Liu Chun-Feng, Cai Xu-Xu, Xu Wei

机构信息

Department of Pediatrics, Second Affiliated Hospital, China Medical University, Shenyang 110004, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2006 Feb;8(1):17-20.

PMID:16522232

Abstract

OBJECTIVE

To investigate the ability of serum procalcitonin (PCT) to differentiate between bacterial and viral meningitis.

METHODS

The serum PCT levels were measured in 41 children with acute bacterial (n=18) or viral (n=23) meningitis by immunoluminometric assay. Meanwhile serum CRP levels and erythrocyte sedimentation rate (ESR) were measured.

RESULTS

The children with acute bacterial meningitis had higher levels of PCT (51.73 +/- 30.75 microg/L) and CRP(182.36 +/- 54.5 mg/L) and ESR (50.44 +/- 8.95 mm/h) than those with viral meningitis (0.84 +/- 0.99 microg/L, 8.90 +/- 10.66 mg/L and 16.75 +/- 13.23 mm/h respectively, P < 0.01). Both PCT and CRP had high predictive value for bacterial meningitis based on the area under curve of the receiver operating characteristics curves, 0.984 for PCT (95% confidence interval 0.953-1.013) and 0.983 for CRP (95% confidence interval 0.954-1.012) (P > 0.05). All of the children with bacterial meningitis had serum PCT levels above 0.5 microg/L, but only 2 patients with viral meningitis exceeded this value.

CONCLUSIONS

The measurement of serum PCT levels may be of value in the differential diagnosis of meningitis due to either bacterial or viruses.

摘要

目的

探讨血清降钙素原（PCT）区分细菌性和病毒性脑膜炎的能力。

方法

采用免疫发光分析法测定41例急性细菌性脑膜炎（n = 18）或病毒性脑膜炎（n = 23）患儿的血清PCT水平。同时测定血清CRP水平和红细胞沉降率（ESR）。

结果

急性细菌性脑膜炎患儿的PCT（51.73±30.75μg/L）、CRP（182.36±54.5mg/L）和ESR（50.44±8.95mm/h）水平高于病毒性脑膜炎患儿（分别为0.84±0.99μg/L、8.90±10.66mg/L和16.75±13.23mm/h，P < 0.01）。基于受试者工作特征曲线的曲线下面积，PCT和CRP对细菌性脑膜炎均具有较高的预测价值，PCT为0.984（95%置信区间0.953 - 1.013），CRP为0.983（95%置信区间0.954 - 1.012）（P > 0.05）。所有细菌性脑膜炎患儿的血清PCT水平均高于0.5μg/L，但只有2例病毒性脑膜炎患儿超过该值。