[紫杉醇洗脱支架对再狭窄的影响]

[The effect of paclitaxel-eluting stents on restenosis].

作者信息

Kurşaklioğlu Hürkan, Köz Cem, Iyisoy Atilla, Ide Tayfun, Yildirim Vedat, Töre Hasan Fehmi, Işik Ersoy, Demirtaş Ertan

机构信息

Gülhane Askeri Tip Akademisi Kardiyoloji, Anabilim Dallari, Ankara, Türkiye.

出版信息

Anadolu Kardiyol Derg. 2006 Mar;6(1):18-23.

PMID:16524795

Abstract

OBJECTIVE

In our study we aimed to investigate the effects of paclitaxel-eluting stent on restenosis.

METHODS

Sixteen porcine were randomly assigned to two groups (n=8 per group): control group animals received conventional stent implantation and study group animals -paclitaxel-eluting stent implantation. Both groups were treated with 300 mg acetylsalicylic acid and 75 mg clopidogrel daily. The degree of neointimal proliferation and effect of drug-eluting stent on restenosis were evaluated 6 weeks after by angiography and intravascular ultrasound (IVUS).

RESULTS

Angiographic in-stent restenosis was lower in paclitaxel-eluting stent group (12.50 +/- 7.07% versus 41.25 +/- 28.50%, p=0.001). The IVUS data demonstrated that paclitaxel group animals had larger minimal lumen area (8.76 +/- 1.09 mm2 versus 6.23 +/- 3.10 mm2, p=0.028), smaller mean neointimal proliferation area (1.03 +/- 0.75 mm2 versus 3.55 +/- 2.86 mm2, p=0.01) and mean percent stenosis (10.71 +/- 8.10% versus 36.85 +/- 30.93%, p=0.01).

CONCLUSION

This study suggests that drug-eluting stents may also have a preventive effect for the in-stent restenosis.

摘要

目的

在我们的研究中，旨在探讨紫杉醇洗脱支架对再狭窄的影响。

方法

16头猪被随机分为两组（每组n = 8）：对照组动物接受传统支架植入，研究组动物接受紫杉醇洗脱支架植入。两组均每日给予300毫克阿司匹林和75毫克氯吡格雷治疗。6周后通过血管造影和血管内超声（IVUS）评估新生内膜增生程度和药物洗脱支架对再狭窄的影响。

结果

紫杉醇洗脱支架组的血管造影支架内再狭窄率较低（12.50±7.07%对41.25±28.50%，p = 0.001）。IVUS数据显示，紫杉醇组动物的最小管腔面积较大（8.76±1.09平方毫米对6.23±3.10平方毫米，p = 0.028），平均新生内膜增生面积较小（1.03±0.75平方毫米对3.55±2.86平方毫米，p = 0.01），平均狭窄百分比也较小（10.71±8.10%对36.85±30.93%，p = 0.01）。