Mezei Gabor, Borugian Marilyn J, Spinelli John J, Wilkins Russell, Abanto Zenaida, McBride Mary L
Environment Division, Electric Power Research Institute, Palo Alto, CA 94304, USA.
Am J Epidemiol. 2006 Jul 15;164(2):170-5. doi: 10.1093/aje/kwj118. Epub 2006 Mar 8.
The authors examined the relation between neighborhood income, as a measure of socioeconomic status, and childhood cancer. Incident cases of childhood solid tumor and lymphoma in 1985-2001 were identified from provincial cancer registries in Canada. Residential postal codes at the time of diagnosis were used to assign cases to census neighborhoods. Person-years at risk were determined from quintiles of population by neighborhood income, sex, and 5-year age group, constructed using census population data. Poisson regression was used to calculate incidence rate ratios across neighborhood income quintiles. Compared with the incidence rate in the richest income quintile, moderately lower rate ratios of 0.73 (95% confidence interval: 0.63, 0.86) and 0.84 (95% confidence interval: 0.69, 1.04) were observed, respectively, for carcinomas and renal tumors in the poorest income quintile. No association was found for other types of cancer. Although a potential relation between socioeconomic status and childhood cancer cannot be excluded, the overall pattern seems compatible with random variation.
作者研究了作为社会经济地位衡量指标的邻里收入与儿童癌症之间的关系。1985年至2001年期间加拿大省级癌症登记处确诊的儿童实体瘤和淋巴瘤发病病例。诊断时的居住邮政编码用于将病例分配到人口普查邻里。风险人年根据邻里收入、性别和5岁年龄组的人口五分位数确定，使用人口普查人口数据构建。采用泊松回归计算各邻里收入五分位数的发病率比。与收入最高五分位数的发病率相比，收入最低五分位数的癌症和肾肿瘤发病率比分别适度降低，为0.73（95%置信区间：0.63，0.86）和0.84（95%置信区间：0.69，1.04）。未发现其他类型癌症存在关联。虽然不能排除社会经济地位与儿童癌症之间的潜在关系，但总体模式似乎与随机变异相符。
