Burns Matthew, Baker Joanne, Auliff Alyson M, Gatton Michelle L, Edstein Michael D, Cheng Qin
Medical Emergency Relief International, London, United Kingdom.
Am J Trop Med Hyg. 2006 Mar;74(3):361-6.
The efficacy of sulfadoxine-pyrimethamine (SP) in East Timor is unknown. We treated 38 individuals with uncomplicated Plasmodium falciparum malaria with SP and monitored the outcome for 28 days. Recrudescent parasitemia, confirmed by genotyping, were detected in three individuals resulting in a late treatment failure rate of 7.9% (95% confidence interval = 1.7-21.4%). The results suggest that SP is still efficacious in treating uncomplicated P. falciparum malaria in East Timor. However, the useful life of SP in East Timor may be limited because 80% of the parasites in our samples were found to already carry double mutations in P. falciparum dihydrofolate reductase (S108N/C59R). The data from this study also highlights that the presence of gametocytes may significantly influence the estimate of SP efficacy determined by genotyping.
周效磺胺-乙胺嘧啶（SP）在东帝汶的疗效尚不清楚。我们用SP治疗了38例非复杂性恶性疟原虫疟疾患者，并对结果进行了28天的监测。通过基因分型确认，在3例患者中检测到复发性寄生虫血症，导致晚期治疗失败率为7.9%（95%置信区间=1.7-21.4%）。结果表明，SP在治疗东帝汶非复杂性恶性疟原虫疟疾方面仍然有效。然而，SP在东帝汶的使用寿命可能有限，因为我们样本中80%的寄生虫已被发现携带恶性疟原虫二氢叶酸还原酶的双重突变（S108N/C59R）。这项研究的数据还突出表明，配子体的存在可能会显著影响通过基因分型确定的SP疗效估计。
