Hui M B, Chen D C, Lien E J
School of Pharmacy, Pharmaceutics and Medicinal Chemistry, Radiology Department, University of Southern California, Los Angeles 90033.
Int J Rad Appl Instrum A. 1991;42(6):503-8. doi: 10.1016/0883-2889(91)90152-q.
In the search for new brain imaging agents for the use with single photon emission computed tomography (SPECT), quantitative structure activity relationship (QSAR) analysis of the correlations between initial brain uptake and physicochemical parameters like lipophilicity, log P, molecular weight, log MW and log U/D (undissociated/dissociated), of the 99mTc-DADT (diaminedithiol) complexes and 99mTc-PAO (propyleneamineoxime) complexes have been analyzed. High correlations are found for both the 99mTc-DADT complexes (r = 0.94) and for the 99mTc-PAO complexes (r = 0.83) which are significant at 99.9 and 99.5 percentile level, respectively. These results will help the further design of better ligands for 99mTc in brain imaging.
在寻找用于单光子发射计算机断层扫描（SPECT）的新型脑成像剂时，已对99mTc-DADT（二胺二硫醇）配合物和99mTc-PAO（丙二胺肟）配合物的初始脑摄取与亲脂性、log P、分子量、log MW和log U/D（未解离/解离）等物理化学参数之间的相关性进行了定量构效关系（QSAR）分析。99mTc-DADT配合物（r = 0.94）和99mTc-PAO配合物（r = 0.83）均发现高度相关，分别在99.9%和99.5%的百分位数水平上具有显著性。这些结果将有助于进一步设计用于脑成像的99mTc更好的配体。
