犬基底动脉和足背动脉对去氧肾上腺素、可乐定和5-羟色胺反应的差异。
Differences in the responses of the canine basilar and dorsal pedal artery to phenylephrine, clonidine and serotonin.
作者信息
Sotníková R, Gibala P
机构信息
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava.
出版信息
Methods Find Exp Clin Pharmacol. 1991 Jul-Aug;13(6):427-33.
The effects of phenylephrine, clonidine and serotonin were studied on isolated preparations of the canine basilar and dorsal pedal artery. Differences were mainly observed in the responses of the two types of arterial preparations to clonidine and phenylephrine. While in the dorsal pedal artery, alpha 1- and alpha 2-receptors were involved in the response to alpha-agonists, in the basilar artery contractions induced by alpha 2-receptor stimulation prevailed. Moreover, in the latter artery the contractile responses induced by each of the agonists used were more dependent on the presence of extracellular calcium than those in the dorsal pedal artery.
研究了去氧肾上腺素、可乐定和5-羟色胺对犬基底动脉和足背动脉离体标本的作用。主要观察到这两种动脉标本对可乐定和去氧肾上腺素的反应存在差异。在足背动脉中，α1和α2受体参与了对α激动剂的反应，而在基底动脉中，α2受体刺激诱导的收缩占主导。此外，在后一种动脉中，每种使用的激动剂诱导的收缩反应比足背动脉更依赖细胞外钙的存在。
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