Konnov B A, Konnova L A, Lebedeva N A, Shalek R A
Med Radiol (Mosk). 1991;36(7):16-8.
The composition and blood concentration of free aminoacids and other aminocompounds were investigated using automatic aminoacid analysis by a physiological program in 12 patients with diagnosed corticotropin secreting hypophyseal disease (Itsenko-Cushing disease) before and 1-3 years after proton "hypophysectomy". Imbalance of components of the glucose-alanine cycle, expressed in hypoalaninemia and raised concentration of aminoacids with a bifurcated lateral chain, was detected against a background of marked hypercorticotropinemia and hypercorticolism. Single irradiation of the pituitary gland with a proton beam at absorbed doses of 100-120 Gy in the maximum of a deep field resulted in remission and normalization of aminograms of blood plasma (suggesting pathogenicity of proton-beam therapy) for 6-12 mos. The authors discussed probable mechanisms of the interrelationship of protein-amino-acid and carbohydrate metabolic derangements and their correlation with a type of changes in the hormonal balance.
利用自动氨基酸分析仪，按照生理学程序，对12例已确诊的促肾上腺皮质激素分泌性垂体疾病（库欣病）患者在质子“垂体切除”术前以及术后1至3年时的游离氨基酸和其他氨基化合物的组成及血药浓度进行了研究。在显著的高促肾上腺皮质激素血症和高皮质醇血症背景下，检测到葡萄糖 - 丙氨酸循环成分失衡，表现为低丙氨酸血症以及具有分叉侧链的氨基酸浓度升高。在深野最大剂量处给予垂体100 - 120 Gy吸收剂量的质子束单次照射，可使血浆氨基酸谱在6至12个月内缓解并恢复正常（提示质子束疗法具有致病性）。作者讨论了蛋白质 - 氨基酸和碳水化合物代谢紊乱相互关系的可能机制，以及它们与激素平衡变化类型的相关性。
