Effective mucus clearance is essential for respiratory health.
作者信息
Randell Scott H, Boucher Richard C
机构信息
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, USA.
出版信息
Am J Respir Cell Mol Biol. 2006 Jul;35(1):20-8. doi: 10.1165/rcmb.2006-0082SF. Epub 2006 Mar 9.
Abstract
摘要
相似文献
1
Effective mucus clearance is essential for respiratory health.有效的黏液清除对呼吸道健康至关重要。
Am J Respir Cell Mol Biol. 2006 Jul;35(1):20-8. doi: 10.1165/rcmb.2006-0082SF. Epub 2006 Mar 9.
2
Mucus clearance as a primary innate defense mechanism for mammalian airways.黏液清除作为哺乳动物气道的一种主要先天性防御机制。
J Clin Invest. 2002 Mar;109(5):571-7. doi: 10.1172/JCI15217.
3
[Mucus clearance in the respiratory tract: a new concept?].[呼吸道中的黏液清除：一个新概念？]
Med Sci (Paris). 2013 Feb;29(2):144-6. doi: 10.1051/medsci/2013292010. Epub 2013 Feb 28.
4
Mucociliary clearance--a critical upper airway host defense mechanism and methods of assessment.黏液纤毛清除功能——一种关键的上呼吸道宿主防御机制及评估方法。
Curr Opin Allergy Clin Immunol. 2007 Feb;7(1):5-10. doi: 10.1097/ACI.0b013e3280114eef.
5
[The significance of muco-ciliary clearance as a defense mechanism in the respiratory tract].[黏液纤毛清除作为呼吸道防御机制的意义]
Pneumonol Alergol Pol. 1996;64(11-12):821-8.
6
[Natural defense mechanisms of the respiratory tract in the otolaryngological aspect].[耳鼻咽喉科视角下呼吸道的自然防御机制]
Przegl Lek. 1990;47(4):406-11.
7
Effects of cigarette smoke on epithelial cells of the respiratory tract.香烟烟雾对呼吸道上皮细胞的影响。
Thorax. 1994 Aug;49(8):825-34. doi: 10.1136/thx.49.8.825.
8
9
Airway mucus.气道黏液
Eur Respir J. 1997 Jul;10(7):1438. doi: 10.1183/09031936.97.10071438.
10
Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: lessons from mouse models.纤毛、黏液和气道表面液体在黏液纤毛功能障碍中的作用：来自小鼠模型的经验教训。
J Aerosol Med Pulm Drug Deliv. 2008 Mar;21(1):13-24. doi: 10.1089/jamp.2007.0659.
引用本文的文献
1
Cilia dynamics create a dynamic barrier to penetration of the periciliary layer in human airway epithelia.纤毛动力学对人呼吸道上皮细胞周纤毛层的穿透形成了动态屏障。
Proc Natl Acad Sci U S A. 2025 Jul 15;122(28):e2419032122. doi: 10.1073/pnas.2419032122. Epub 2025 Jul 11.
2
Nanoparticle Dynamics near Polyacrylamide Gel Interfaces.聚丙烯酰胺凝胶界面附近的纳米颗粒动力学
ACS Polym Au. 2025 Mar 28;5(3):261-269. doi: 10.1021/acspolymersau.4c00099. eCollection 2025 Jun 11.
3
Modulation of pulmonary immune functions by the secondary metabolite pyocyanin.次生代谢产物绿脓菌素对肺部免疫功能的调节作用。
Front Immunol. 2025 Mar 24;16:1550724. doi: 10.3389/fimmu.2025.1550724. eCollection 2025.
4
Esc peptides and derivatives potentiate the activity of CFTR with gating defects and display antipseudomonal activity in cystic fibrosis-like lung disease.Esc肽及其衍生物可增强具有门控缺陷的囊性纤维化跨膜传导调节因子（CFTR）的活性，并在类囊性纤维化肺病中表现出抗铜绿假单胞菌活性。
Cell Mol Life Sci. 2025 Mar 18;82(1):121. doi: 10.1007/s00018-025-05633-9.
5
Structure and function relationships of mucociliary clearance in human and rat airways.人类和大鼠气道中黏液纤毛清除的结构与功能关系
Nat Commun. 2025 Mar 12;16(1):2446. doi: 10.1038/s41467-025-57667-z.
6
Wirelessly Actuated Ciliary Airway Stent for Excessive Mucus Transportation.用于过度黏液运输的无线驱动纤毛气道支架
Adv Mater Technol. 2023 Dec 13;8(23). doi: 10.1002/admt.202301003. Epub 2023 Oct 31.
7
Changing profile of bacterial infection and microbiome in cystic fibrosis: when to use antibiotics in the era of CFTR-modulator therapy.囊性纤维化中细菌感染和微生物群的变化概况：在CFTR调节剂治疗时代何时使用抗生素。
Eur Respir Rev. 2024 Dec 4;33(174). doi: 10.1183/16000617.0068-2024. Print 2024 Oct.
8
Impact of N-Acetylcysteine on Mucus Hypersecretion in the Airways: A Systematic Review.N-乙酰半胱氨酸对气道黏液高分泌的影响：系统评价。
Int J Chron Obstruct Pulmon Dis. 2024 Oct 29;19:2347-2360. doi: 10.2147/COPD.S474512. eCollection 2024.
9
Single-cell RNA sequencing reveals heterogeneity of ALI model and epithelial cell alterations after exposure to electronic cigarette aerosol.单细胞RNA测序揭示了暴露于电子烟烟雾后ALI模型的异质性和上皮细胞变化。
Heliyon. 2024 Sep 26;10(19):e38552. doi: 10.1016/j.heliyon.2024.e38552. eCollection 2024 Oct 15.
10
Anti-Inflammatory and Anti-Oxidant Properties of N-Acetylcysteine: A Fresh Perspective.N-乙酰半胱氨酸的抗炎和抗氧化特性：一个新视角。
J Clin Med. 2024 Jul 15;13(14):4127. doi: 10.3390/jcm13144127.
本文引用的文献
1
2
Mucus clearance and lung function in cystic fibrosis with hypertonic saline.高渗盐水用于囊性纤维化患者的黏液清除与肺功能研究
N Engl J Med. 2006 Jan 19;354(3):241-50. doi: 10.1056/NEJMoa043891.
3
A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis.一项针对囊性纤维化患者长期吸入高渗盐水的对照试验。
N Engl J Med. 2006 Jan 19;354(3):229-40. doi: 10.1056/NEJMoa043900.
4
Relationship of airway epithelial ion transport to chronic bronchitis.气道上皮离子转运与慢性支气管炎的关系。
Proc Am Thorac Soc. 2004;1(1):66-70. doi: 10.1513/pats.2306018.
5
Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections.正常和囊性纤维化气道表面液体稳态。相切应力和病毒感染的影响。
J Biol Chem. 2005 Oct 21;280(42):35751-9. doi: 10.1074/jbc.M505832200. Epub 2005 Aug 8.
6
Reduced three-dimensional motility in dehydrated airway mucus prevents neutrophil capture and killing bacteria on airway epithelial surfaces.脱水气道黏液中三维运动能力的降低会阻碍中性粒细胞在气道上皮表面捕获和杀灭细菌。
J Immunol. 2005 Jul 15;175(2):1090-9. doi: 10.4049/jimmunol.175.2.1090.
7
Bacterial activity in cystic fibrosis lung infections.囊性纤维化肺部感染中的细菌活性。
Respir Res. 2005 Jun 1;6(1):49. doi: 10.1186/1465-9921-6-49.
8
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus.哮喘支气管上皮细胞对鼻病毒感染的固有免疫反应存在缺陷。
J Exp Med. 2005 Mar 21;201(6):937-47. doi: 10.1084/jem.20041901.
9
Chronic airway infection/inflammation induces a Ca2+i-dependent hyperinflammatory response in human cystic fibrosis airway epithelia.慢性气道感染/炎症在人类囊性纤维化气道上皮细胞中诱导一种依赖于细胞内钙离子（Ca2+i）的高炎症反应。
J Biol Chem. 2005 May 6;280(18):17798-806. doi: 10.1074/jbc.M410618200. Epub 2005 Mar 3.
10
Characterization of wild-type and deltaF508 cystic fibrosis transmembrane regulator in human respiratory epithelia.人类呼吸道上皮中野生型和ΔF508囊性纤维化跨膜传导调节因子的特性分析。
Mol Biol Cell. 2005 May;16(5):2154-67. doi: 10.1091/mbc.e04-11-1010. Epub 2005 Feb 16.
Zotero 插件