Coyne K P, Reed F C, Porter C J, Dawson S, Gaskell R M, Radford A D
Department of Veterinary Clinical Sciences, University of Liverpool Veterinary Teaching Hospital, Leahurst, Chester High Road, Neston, South Wirral CH64 7TE, UK.
Department of Veterinary Pathology, University of Liverpool Veterinary Teaching Hospital, Leahurst, Chester High Road, Neston, South Wirral CH64 7TE, UK.
J Gen Virol. 2006 Apr;87(Pt 4):921-926. doi: 10.1099/vir.0.81537-0.
To understand the evolution of the family Caliciviridae, the persistence of Feline calicivirus (FCV) was studied within an endemically infected cat colony. Polymerase and capsid sequences were analysed for 34 FCV isolates obtained over a 4 year period. Initially, the colony was infected with one strain of virus, but a second distinct strain was later identified. Subsequently, the emergence of a recombinant virus was observed, containing elements of both of the strains circulating within the colony. The recombination event mapped close to the ORF1/ORF2 junction. This is consistent with recombination in other caliciviruses, suggesting a common mechanism within this family. This is the first report of recombination within the genus Vesivirus in the family Caliciviridae and the first time that a recombination event has been observed where the parental strains have also been identified.
为了解杯状病毒科的进化情况，在一个地方性感染猫群中研究了猫杯状病毒（FCV）的持续性。对在4年期间获得的34株FCV分离株的聚合酶和衣壳序列进行了分析。最初，该猫群感染了一种病毒株，但后来鉴定出了第二种不同的病毒株。随后，观察到一种重组病毒的出现，其包含在该猫群中传播的两种病毒株的元件。重组事件定位于靠近ORF1/ORF2连接处。这与其他杯状病毒中的重组情况一致，表明该科内存在共同机制。这是杯状病毒科水疱病毒属内重组的首次报道，也是首次观察到重组事件且鉴定出亲本病毒株的情况。
