Lambert Michael Tedford
Department of Psychiatry, University of Texas South-Western Medical School at Dallas (UTSWMS), Texas 76104, USA.
Int Clin Psychopharmacol. 2006 May;21(3):185-7. doi: 10.1097/01.yic.0000185021.48279.00.
The present study illustrates the potential use of aripiprazole as part of the management of post-traumatic stress disorder (PTSD) in returning Global War on Terrorism (GWOT) veterans. Five consecutive cases of GWOT combat-related PTSD, managed in part with the atypical antipsychotic medication aripiprazole, are presented and discussed. In four of the five cases reported, the medication was well-tolerated and was effective in the management of sleep disturbances, such as nightmares and agitated behaviours during sleep, and was also helpful in the management of hyper-arousal. In one case, the veteran experienced a paradoxical excitation response to the medication. Aripiprazole, in conjunction with other medications or psychotherapeutic interventions, should be studied further for its potential role in the management of PTSD.
本研究阐明了阿立哌唑作为治疗从全球反恐战争（GWOT）归来的退伍军人创伤后应激障碍（PTSD）的一部分的潜在用途。本文呈现并讨论了连续五例与GWOT战斗相关的PTSD病例，这些病例部分采用非典型抗精神病药物阿立哌唑进行治疗。在报告的五例病例中的四例中，该药物耐受性良好，对睡眠障碍（如噩梦和睡眠期间的激越行为）的管理有效，并且对过度觉醒的管理也有帮助。在一例病例中，该退伍军人对该药物出现了反常的兴奋反应。阿立哌唑与其他药物或心理治疗干预措施联合使用在PTSD管理中的潜在作用应进一步研究。
