Uchaĭkin V F, Udovichenko D V, Kaganov B S, Granovskiĭ N N, Uspenskiĭ M V, Viazov S O, Stepanov A N, Syr'eva T N, Cherednichenko T V, Khlopova I V
Vopr Virusol. 1991 Mar-Apr;36(2):120-2.
The presence of HBV DNA in the blood serum of 50 children with HBsAg-positive chronic hepatitis (36 with chronic hepatitis B, 14 with chronic hepatitis delta) was determined by molecular hybridization method. No significant differences were observed between the frequency of HBV DNA detection and clinicomorphological type of chronic HBsAg-positive hepatitis. In chronic HBV infection, HBV DNA was shown to be detected more frequently than in chronic hepatitis delta. A correlation was confirmed between the frequency of HBV DNA detection and demonstration of HBeAg in the blood. With the increase in the duration of the disease and age of the patients the HBV DNA detection rate was found to diminish.
采用分子杂交法测定了50例HBsAg阳性慢性肝炎患儿（36例慢性乙型肝炎，14例慢性丁型肝炎）血清中的HBV DNA。HBsAg阳性慢性肝炎的HBV DNA检测频率与临床形态学类型之间未观察到显著差异。在慢性HBV感染中，HBV DNA的检测频率高于慢性丁型肝炎。证实了HBV DNA检测频率与血液中HBeAg的显示之间存在相关性。随着病程延长和患者年龄增加，发现HBV DNA检测率降低。
