通过将碱性成纤维细胞生长因子（bFGF）负载微球整合到胶原膜中促进伤口愈合
[Promotion of wound healing through incorporation of bFGF-impregnated microspheres into collagen membrane].
作者信息
Huang Sha, Jin Yan, Deng Tianzheng, Wu Hong, Liu Tao, Liu Jianming
机构信息
Tissue Engineering Center, Stomatological College, Fourth Military Medical University, Xi'an, Shaanxi 710032, P R China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2006 Feb;20(2):161-4.
OBJECTIVE
To investigate the promotion effects of the collagen membrane incorporating bFGF-impregnated microspheres on the wound healing of the pig skin losing its full-thickness layers.
METHODS
The bFGF containing microspheres was added into the dry microspheres. The collagen membranes were prepared by incorporating bFGF-impregnated microspheres, and 6 York pig models of skin wounds with loss of their full-thickness layers were established for the observation of the effects on the wound healing.
RESULTS
The healing time and the 28-day healing rate were 27.30 +/- 1.14 days and 98. 12% +/- 1.97%, respectively. The healing rate was significantly higher and the healing time was significantly shorter in the experimental group than in the control group (P < 0.05). The histological examination showed that the proliferation condition of the epidermis was also much better in the experimental group.
CONCLUSION
Incorporation of bFGF-impregnated microspheres into the collagen membrane is a promising method of promoting the healing of the wound with a loss of the full-thickness skin.
目的
探讨含碱性成纤维细胞生长因子（bFGF）微球的胶原膜对猪全层皮肤缺损创面愈合的促进作用。
方法
将含bFGF的微球加入干燥微球中。制备含bFGF微球的胶原膜，并建立6只约克猪全层皮肤缺损创面模型，观察其对创面愈合的影响。
结果
愈合时间和28天愈合率分别为27.30±1.14天和98.12%±1.97%。实验组的愈合率显著高于对照组，愈合时间显著短于对照组（P<0.05）。组织学检查显示，实验组表皮的增殖情况也明显更好。
结论
将含bFGF微球的胶原膜应用于全层皮肤缺损创面的愈合是一种很有前景的方法。
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