Wei L N, Chen G J
Department of Microbiology/Immunology, Chang Gung Medical College, Tao-Yuan, Taiwan, R.O.C.
Biochem Biophys Res Commun. 1991 Aug 30;179(1):210-6. doi: 10.1016/0006-291x(91)91356-h.
Transgenic mice with ectopic expression of bovine cellular retinoic acid-binding protein (CRABP) under the control of human metallothionein IIA promoter have been generated. From a total of 10 independent transgenic live borns, six lines have expressed the bovine CRABP messages in a variety of tissues. Among the six lines, three appear to be normal and healthy in the founders as well as their offspring, one has generated transgenic offspring with retarded growth and two have produced only female transgenic mice that are all sterile.
已培育出在人金属硫蛋白IIA启动子控制下异位表达牛细胞视黄酸结合蛋白（CRABP）的转基因小鼠。在总共10只独立出生的转基因活体小鼠中，有6个品系在多种组织中表达了牛CRABP信息。在这6个品系中，3个品系的奠基者及其后代看起来正常健康，1个品系产生了生长发育迟缓的转基因后代，还有2个品系只产生了全部不育的雌性转基因小鼠。
