Mulatero Paolo, Milan Alberto, Williams Tracy Ann, Veglio Franco
Ospedale San Vito, Strada San Vito 34, 10133 Torino, Italy.
Cardiovasc Hematol Agents Med Chem. 2006 Jan;4(1):75-91. doi: 10.2174/187152506775268776.
Over the last decade a wealth of studies have shed new light on the role of aldosterone in the pathogenesis of cardiovascular diseases. It is now evident that in addition to its classical role in increasing sodium re-absorbtion in the kidney , aldosterone also exhibits several nonepithelial effects such as the induction of inflammation, fibrosis and necrosis in various organs. Herein we review the experimental evidences for the protective effects of mineralocorticoid receptor blockade in the prevention and treatment of target organ damage, both in animals and in humans. We also discuss the pharmacological and clinical differences between the two available mineralocorticoid receptor blockers, spironolactone and eplerenone.
在过去十年中，大量研究为醛固酮在心血管疾病发病机制中的作用带来了新的认识。现在很明显，除了其在增加肾脏钠重吸收方面的经典作用外，醛固酮还表现出多种非上皮效应，如在各个器官中诱导炎症、纤维化和坏死。在此，我们综述了在动物和人类中，盐皮质激素受体阻断在预防和治疗靶器官损伤方面的保护作用的实验证据。我们还讨论了两种可用的盐皮质激素受体阻断剂螺内酯和依普利酮在药理学和临床方面的差异。
