白细胞介素6和肿瘤坏死因子可完全激活C4b结合蛋白α链的肝脏特异性基因表达。
Interleukin 6 and tumor necrosis factor fully activate liver-specific gene expression of the alpha chain of C4b-binding protein.
作者信息
Matsuguchi T, Okamura S, Aso T, Takahashi K, Sata T, Niho Y
机构信息
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
出版信息
Biochem Int. 1991 Mar;23(5):979-85.
We investigated the gene expression of the alpha chain of C4b-binding protein (C4bp alpha) in a variety of tissues, and in liver cell and hepatoma lines. C4bp alpha mRNA was detected in the liver, but not in the other tissues examined. The constitutive gene expression of C4bp alpha by a hepatoma line, HepG2, was significantly augmented by treatment with monocyte-conditioned medium (MoCM), 12-O-tetradecanoylphorbol-13-acetate (TPA), interleukin-6 (IL6) and tumor necrosis factor (TNF) but not by a calcium ionophore (A23187) or interleukin-1 beta (IL1 beta).
我们研究了C4b结合蛋白α链（C4bpα）在多种组织、肝细胞系和肝癌细胞系中的基因表达。在肝脏中检测到了C4bpα mRNA，但在其他检测的组织中未检测到。肝癌细胞系HepG2对C4bpα的组成型基因表达，经单核细胞条件培养基（MoCM）、12-O-十四烷酰佛波醇-13-乙酸酯（TPA）、白细胞介素-6（IL6）和肿瘤坏死因子（TNF）处理后显著增强，但经钙离子载体（A23187）或白细胞介素-1β（IL1β）处理后未增强。
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