Sakly G, Hellara O, Trabelsi A, Dogui M
Service d'explorations fonctionnelles du système nerveux, hôpital universitaire Sahloul, 4054, Sousse.
Neurophysiol Clin. 2005 Nov-Dec;35(5-6):149-53. doi: 10.1016/j.neucli.2005.12.001. Epub 2006 Jan 25.
To describe an electroclinical presentation of a peripheral neuropathy in a patient who suffered from vitamin B12 deficiency.
We report the case of a 56-year-old man who, 17 years after a subtotal gastrectomy, presented with a diffuse sensory-motor demyelinating peripheral neuropathy with multifocal alteration of conduction confirmed by electromyography. Its causal relationship with vitamin B12 deficiency was biologically demonstrated. This neuropathy improved within a few days after intramuscular hydroxocobalamin treatment. Both clinical and electrophysiological signs had totally disappeared 3 months later on.
This observation demonstrates that, in spite of its poor outcome reported by several authors, peripheral neuropathy induced by vitamin B12 deficiency can recover completely with substitutive treatment.
描述一名维生素B12缺乏患者的周围神经病变的临床电生理表现。
我们报告了一名56岁男性的病例,该患者在次全胃切除术后17年,出现弥漫性感觉运动性脱髓鞘周围神经病变,肌电图证实存在多灶性传导改变。其与维生素B12缺乏的因果关系通过生物学方法得以证实。该神经病变在肌肉注射羟钴胺素治疗后几天内有所改善。3个月后临床和电生理体征完全消失。
该观察结果表明,尽管有几位作者报道其预后不佳,但维生素B12缺乏所致的周围神经病变经替代治疗可完全恢复。