Delberghe X, Brunko E, Zegers de Beyl D
Service de Neurologie, Hôpital Erasme, Bruxelles, Belgique.
Rev Neurol (Paris). 1991;147(11):723-6.
We report clinical and neurophysiological data of a 58 year-old man with vitamin B12 deficiency and a 6 years follow-up. The initial clinical disorders did not permit a clear distinction between peripheral and central nervous system disease. Detailed analysis of the somatosensory central conduction time (measured from onset latencies of N11 and N20) showed clear evidence of slowed down conduction at spinal cervical level (reflected by the N11-P14 interval) whereas supraspinal conduction (as shown by the P14-N20 interval) was normal. The patient's condition improved under treatment, and the somatosensory central conduction time was progressively shortened. After 6 years of treatment, the neurological examination and the somatosensory central conduction interval were normal. However, analysis of the spinal conduction still showed slowed down conduction.
我们报告了一名58岁维生素B12缺乏男性患者的临床和神经生理学数据以及6年的随访情况。最初的临床病症无法明确区分周围神经系统疾病和中枢神经系统疾病。对体感中枢传导时间（从N11和N20的起始潜伏期测量）的详细分析显示，在颈椎水平存在传导减慢的明确证据（由N11 - P14间期反映），而上脊髓传导（如P14 - N20间期所示）正常。患者在治疗后病情改善，体感中枢传导时间逐渐缩短。经过6年治疗，神经学检查和体感中枢传导间期均正常。然而，对脊髓传导的分析仍显示传导减慢。
