Natoli Gioacchino
Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy.
FEBS Lett. 2006 May 22;580(12):2843-9. doi: 10.1016/j.febslet.2006.02.072. Epub 2006 Mar 6.
NF-kappaB is a collective name given to a family of ubiquitous transcription factors (TFs) activated in response to inflammatory stimuli and environmental stressors, and required for the activation of many crucial inflammatory and immune response genes. NF-kappaB is activated by degradation of its cytoplasmic anchors, the IkappaBs, and subsequent nuclear translocation and accumulation. Once entered in the nucleus NF-kappaB activates transcription of hundreds of genes; however, each inflammatory gene must be expressed and turned off with peculiar kinetics that suit its specific function. Chromatin organization plays a major role in controlling the kinetics of NF-kappaB recruitment to target genes and it represents an integration point mediating TF cooperativity.
核因子-κB（NF-κB）是一类普遍存在的转录因子（TFs）的统称，这些转录因子在炎症刺激和环境应激源的作用下被激活，并且是激活许多关键炎症和免疫反应基因所必需的。NF-κB通过其细胞质锚定蛋白IκB的降解、随后的核转位和积累而被激活。一旦进入细胞核，NF-κB就会激活数百个基因的转录；然而，每个炎症基因都必须以适合其特定功能的独特动力学进行表达和关闭。染色质组织在控制NF-κB募集到靶基因的动力学过程中起主要作用，它代表了一个介导转录因子协同作用的整合点。
