1] Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts [2] Division of Newborn Medicine, Department of Neurology, Floating Hospital for Children at Tufts Medical Center,, Boston, Massachusetts [3] Perinatal Neuroepidemiology Unit, Hannover Medical School, Hannover, Germany.
Neuroepidemiology Unit, Children's Hospital, Boston, Massachusetts.
Pediatr Res. 2014 Mar;75(3):376-80. doi: 10.1038/pr.2013.238. Epub 2013 Dec 12.
Exposure to perinatal infection and inflammation is associated with an increased risk for neonatal brain damage and developmental disabilities. In this integrated mechanism review, we discuss evidence in support of the contention that the preterm newborn is capable of intermittent or sustained systemic inflammation (ISSI), which appears to contribute more to adverse neurodevelopmental outcomes in preterm infants than does shorter duration inflammation.
围产期感染和炎症暴露与新生儿脑损伤和发育障碍的风险增加有关。在这个综合机制综述中,我们讨论了支持早产儿能够间歇性或持续性全身炎症(ISSI)的证据,这种炎症似乎比短时间炎症对早产儿的不良神经发育结局的影响更大。