Polyak Kornelia
Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.
Cancer Cell. 2006 Mar;9(3):151-3. doi: 10.1016/j.ccr.2006.02.026.
Early full-term pregnancy is thought to be one of the most effective means of decreasing lifetime breast cancer risk. Paradoxically, young women diagnosed with breast cancer shortly after giving birth have a higher risk of dying from their disease. These seemingly opposing effects have been largely attributed to mammary epithelial stem cell differentiation and precancerous cell proliferation, respectively, induced by pregnancy-associated hormonal changes. However, recent studies suggest that remodeling of the cellular microenvironment and extracellular matrix during pregnancy and involution may contribute to the enhanced invasive and metastatic potential of breast carcinomas and thus lead to their worse clinical outcome.
足月妊娠早期被认为是降低终生患乳腺癌风险的最有效方法之一。矛盾的是，产后不久被诊断出患有乳腺癌的年轻女性死于该疾病的风险更高。这些看似相反的影响在很大程度上分别归因于妊娠相关激素变化诱导的乳腺上皮干细胞分化和癌前细胞增殖。然而，最近的研究表明，妊娠和 involution 期间细胞微环境和细胞外基质的重塑可能有助于增强乳腺癌的侵袭和转移潜力，从而导致其临床结果更差。
