Nagai Takao, Okafuji Teruo, Miyazaki Chiaki, Ito Yuhei, Kamada Makoto, Kumagai Takuji, Yuri Kenji, Sakiyama Hiroshi, Miyata Akiko, Ihara Toshiaki, Ochiai Hitoshi, Shimomura Kunihisa, Suzuki Eitaro, Torigoe Sadayoshi, Igarashi Masahiro, Kase Tetsuo, Okuno Yoshinobu, Nakayama Tetsuo
Vaccine Study Group of the Society of Ambulatory and General Pediatrics of Japan, Takamatsu 760-0002, Japan.
Vaccine. 2007 Mar 30;25(14):2742-7. doi: 10.1016/j.vaccine.2005.11.068. Epub 2006 Jan 31.
To compare the incidence of aseptic meningitis associated with symptomatic natural mumps infection and in mumps vaccine recipients, we conducted a prospective comparative study. Consecutive samples of 1051 children with mumps were enrolled by 10 pediatricians and 21,465 vaccine recipients by 143 pediatric primary care practitioners, from January 1, 2000 to January 1, 2003. Parents used a daily diary to record symptoms during the period of illness (15 days) or 30-day period following immunization. Mumps infection was confirmed by virus isolation and/or detection of mumps virus genome in salivary and CSF samples. The incidence of aseptic meningitis was 13/1051 (1.24%) in patients with symptomatic natural mumps infection and was estimated to be 0.7-1.1% of overall infection in considering asymptomatic infection, and 10/21,465 (0.05%) in vaccine recipients. Although aseptic meningitis is a clear side effect of the mumps vaccine, the incidence is considerably lower than among those with symptomatic natural infection. Our results provide an informative data for consideration to resume mumps vaccine as a part of routine immunization schedule for Japanese children.
为比较有症状的自然感染腮腺炎与腮腺炎疫苗接种者中无菌性脑膜炎的发病率，我们开展了一项前瞻性对照研究。在2000年1月1日至2003年1月1日期间，10名儿科医生招募了1051例腮腺炎患儿的连续样本，143名儿科初级保健医生招募了21465名疫苗接种者。家长们使用每日日记记录患病期间（15天）或免疫接种后30天内的症状。通过病毒分离和/或在唾液及脑脊液样本中检测腮腺炎病毒基因组来确诊腮腺炎感染。有症状的自然感染腮腺炎患者中无菌性脑膜炎的发病率为13/1051（1.24%），若考虑无症状感染，估计在总体感染中的发病率为0.7 - 1.1%，而疫苗接种者中为10/21465（0.05%）。虽然无菌性脑膜炎是腮腺炎疫苗的明确副作用，但其发病率显著低于有症状的自然感染者。我们的结果为考虑恢复腮腺炎疫苗作为日本儿童常规免疫规划的一部分提供了有益的数据参考。
