MacDonald Adam L, Philp Andrew, Harrison Moira, Bone Adrian J, Watt Peter W
School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, United Kingdom.
Med Sci Sports Exerc. 2006 Feb;38(2):201-7. doi: 10.1249/01.mss.0000183852.31164.5a.
The present study determined the efficacy of the Continuous Glucose Monitoring System (CGMS) during moderate exercise and monitored the changes in whole-day glucose profiles using the CGMS in individuals with and without type 2 diabetes.
Six, obese, diet-treated individuals with and four age-matched individuals without type 2 diabetes were monitored using the CGMS for 3 d. Subjects cycled at 90% of a predetermined lactate threshold for 1 h at approximately 09:00 h on day 2, during which venous blood was sampled at 10-min intervals and immediately analyzed for glucose concentrations.
Venous blood glucose and CGMS values declined during exercise in the diabetes (P < 0.001) but not the control group (P = 0.085). The CGMS overestimated blood glucose in the control (P = 0.003) and the diabetes (P = 0.045) groups during exercise. The number of data points outside of the 95% confidence intervals was <5% in both groups, showing that there is a statistically acceptable level of agreement between venous blood glucose and CGMS values during exercise. Moderate exercise improved whole-day average glucose concentrations (P = 0.007) and whole-day area under the glucose curve (P = 0.016) values (AUCglu), and the time spent within +/-10% of fasting venous glucose (FVG) increased in the diabetes group (P = 0.021). No such effects were seen in the control group.
Using continuous glucose monitoring we were able to demonstrate that a period of moderate exercise improved whole-day glycemic control in obese individuals with type 2 diabetes. The CGMS should only be used as an adjunct and not as an alternative to frequent blood glucose sampling when examining the changes in glucose values during exercise in individuals with and without type 2 diabetes.
本研究确定了连续血糖监测系统（CGMS）在中等强度运动期间的有效性，并使用CGMS监测了2型糖尿病患者和非2型糖尿病患者全天血糖谱的变化。
对6名接受饮食治疗的肥胖2型糖尿病患者和4名年龄匹配的非2型糖尿病个体使用CGMS进行了3天的监测。在第2天大约09:00时，受试者以预定乳酸阈值的90%进行1小时的骑行，在此期间每隔10分钟采集静脉血样，并立即分析血糖浓度。
糖尿病组运动期间静脉血糖和CGMS值下降（P < 0.001），而对照组未下降（P = 0.085）。运动期间，CGMS在对照组（P = 0.003）和糖尿病组（P = 0.045）中均高估了血糖。两组中超出95%置信区间的数据点数量均<5%，表明运动期间静脉血糖和CGMS值之间在统计学上具有可接受的一致性水平。中等强度运动改善了全天平均血糖浓度（P = 0.007）和全天血糖曲线下面积（P = 0.016）值（AUCglu），糖尿病组中血糖在空腹静脉血糖（FVG）±10%范围内的时间增加（P = 0.021）。对照组未观察到此类影响。
通过连续血糖监测，我们能够证明一段时间的中等强度运动改善了肥胖2型糖尿病患者的全天血糖控制。在检查2型糖尿病患者和非2型糖尿病患者运动期间血糖值的变化时，CGMS仅应用作辅助手段，而不能替代频繁的血糖采样。
