上位性与长期选择过程中遗传变异的释放

Epistasis and the release of genetic variation during long-term selection.

作者信息

Carlborg Orjan, Jacobsson Lina, Ahgren Per, Siegel Paul, Andersson Leif

机构信息

Linnaeus Centre for Bioinformatics, Uppsala University, Box 598, SE-75124 Uppsala, Sweden.

出版信息

Nat Genet. 2006 Apr;38(4):418-20. doi: 10.1038/ng1761. Epub 2006 Mar 12.

DOI:10.1038/ng1761

PMID:16532011

Abstract

It is an enigma how long-term selection in model organisms and agricultural species can lead to marked phenotypic changes without exhausting genetic variation for the selected trait. Here, we show that the genetic architecture of an apparently major locus for growth in chicken dissects into a genetic network of four interacting loci. The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model.

摘要

在模式生物和农业物种中进行长期选择，如何能在不耗尽所选性状的遗传变异的情况下导致显著的表型变化，这是一个谜。在这里，我们表明，鸡中一个明显的主要生长位点的遗传结构可分解为四个相互作用位点的遗传网络。这个辐射状网络中的相互作用介导的选择反应比单一位点模型预测的要大得多。