Petzinger Ernst, Geyer Joachim
Institute of Pharmacology and Toxicology, Frankfurter Str. 107, 35392, Giessen, Germany.
Naunyn Schmiedebergs Arch Pharmacol. 2006 Mar;372(6):465-75. doi: 10.1007/s00210-006-0042-9. Epub 2006 Mar 11.
This review deals with the drug transporters allowing drugs to enter and leave cells by carrier-mediated pathways. Emphasis is put on liver transporters but systems in gut, kidney, and blood-brain barrier are mentioned as well. Drug-drug interactions on carriers may provoke significant modification in pharmacokinetics as do carrier gene polymorphisms yielding functional carrier protein mutations. An integrated phase concept should reflect the interplay between drug metabolism and drug transport.
本综述涉及通过载体介导途径使药物进出细胞的药物转运体。重点是肝脏转运体，但也提及了肠道、肾脏和血脑屏障中的转运系统。载体上的药物相互作用可能会引起药代动力学的显著改变，载体基因多态性导致功能性载体蛋白突变时也会如此。一个综合的阶段概念应反映药物代谢与药物转运之间的相互作用。
