Galter Dagmar, Westerlund Marie, Carmine Andrea, Lindqvist Eva, Sydow Olof, Olson Lars
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Ann Neurol. 2006 Apr;59(4):714-9. doi: 10.1002/ana.20808.
Leucine-rich repeat kinase 2 (LRRK2) has been linked to Parkinson's disease. Our study explores the expression of LRRK2 in human and rodent brain tissue.
We analyzed LRRK2 gene activity at the cellular level using in situ hybridization.
We found a high and strikingly specific expression of LRRK2 mRNA in rodent striatum and parts of cortex and no signals in dopamine neurons. In human tissue, LRRK2 mRNA was found in the corresponding brain areas caudatus and putamen at lower levels and dopamine neurons were also devoid of LRRK2 mRNA. Expression levels in striatal tissue did not differ between Parkinson's disease patients and control subjects.
Unlike all other genes so far linked to Parkinson's disease, our results demonstrate that LRRK2 expression is particularly high in brain dopaminoceptive areas.
富含亮氨酸重复激酶2（LRRK2）与帕金森病相关。我们的研究探讨LRRK2在人和啮齿动物脑组织中的表达。
我们使用原位杂交在细胞水平分析LRRK2基因活性。
我们发现LRRK2 mRNA在啮齿动物纹状体和部分皮质中高表达且具有显著特异性，在多巴胺能神经元中无信号。在人体组织中，LRRK2 mRNA在相应脑区尾状核和壳核中的表达水平较低，多巴胺能神经元中也没有LRRK2 mRNA。帕金森病患者和对照受试者的纹状体组织中的表达水平没有差异。
与迄今所有其他与帕金森病相关的基因不同，我们的结果表明LRRK2在脑多巴胺感受区的表达特别高。
