Ogwo Morgan N, Sharma Bhupender, Goyal Gunjan, Lakshmanaswamy Rajkumar, Kumar Subodh
Center of Emphasis in Neuroscience, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.
Center of Emphasis in Cancer, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.
Mol Ther Nucleic Acids. 2025 Aug 12;36(3):102673. doi: 10.1016/j.omtn.2025.102673. eCollection 2025 Sep 9.
Parkinson's disease (PD) is a debilitating neurodegenerative condition. Synaptic dysfunctions are associated with the onset and progressive neurodegeneration exhibited in PD. Healthy, active synapses are a prerequisite for non-pathological neurotransmission. When neurotransmission becomes pathological, such as observed in neurodegenerative conditions like PD, the biomolecules found in and around such synapses need distinctive investigation. MicroRNAs (miRNAs) found in neuronal subcellular compartments, such as dendrites, pre-synaptic boutons, and synaptic vesicles, have been garnering attention in neurogenerative diseases. MiRNAs that modulate synaptic activity and synapse function are called synaptic miRNAs. Several miRNAs have been identified that regulate key synaptic proteins; however, information about synaptic miRNAs is largely unknown in PD. In this review, we focused on the most promising synaptic miRNAs, those that are critical for normal synapse function and play a crucial role in PD pathology. We also discussed the synaptic miRNA's interplay with PD-associated synaptic dysfunction. Investigating further how synaptic miRNAs impacts PD pathogenesis may uncover novel etiological information and potential pathways for treatments and a cure for PD.
帕金森病（PD）是一种使人衰弱的神经退行性疾病。突触功能障碍与PD中出现的发病和进行性神经退行性变有关。健康、活跃的突触是正常神经传递的先决条件。当神经传递变得病理性时，如在PD等神经退行性疾病中观察到的那样，在这些突触及其周围发现的生物分子需要进行特殊研究。在神经元亚细胞区室（如树突、突触前终扣和突触小泡）中发现的微小RNA（miRNA）在神经退行性疾病中受到了关注。调节突触活动和突触功能的miRNA被称为突触miRNA。已经鉴定出几种调节关键突触蛋白的miRNA；然而，在PD中，关于突触miRNA的信息大多未知。在这篇综述中，我们聚焦于最有前景的突触miRNA，即那些对正常突触功能至关重要且在PD病理过程中起关键作用的miRNA。我们还讨论了突触miRNA与PD相关突触功能障碍的相互作用。进一步研究突触miRNA如何影响PD发病机制可能会揭示新的病因信息以及治疗和治愈PD的潜在途径。
