Tramposch W G, Weber S G
Department of Chemistry, University of Pittsburgh, PA 15260.
J Chromatogr. 1991 May 17;544(1-2):113-23. doi: 10.1016/s0021-9673(01)83981-9.
A new bonded phase has been prepared by the reaction of n-propylsultone with dimethylaminopropylsilane-modified silica. The resulting functional group is the zwitterionic ammonium propane sulfonate. Chromatographic solvents based on three strong solvents, methylene chloride, diisopropyl ether and acetonitrile, were prepared in hexane. Solutes, including substituted benzenes, polycyclic aromatic hydrocarbons and low-molecular-weight species commonly used as solvents, were chromatographed on the zwitterionic phase and on silica from the same supplier of the dimethylamino phase. The zwitterionic phase is a weaker adsorbent than silica and retentions are less influenced by the type of strong solvent employed, compared to silica. The retention (log k') of solutes on the zwitterionic phase is highly correlated with the free energy of transfer of solute from the vapor phase to water.
通过正丙基磺内酯与二甲基氨基丙基硅烷改性硅胶反应制备了一种新的键合相。所得官能团为两性离子型丙烷磺酸铵。基于二氯甲烷、异丙醚和乙腈这三种强溶剂的色谱溶剂在己烷中配制。包括取代苯、多环芳烃和常用作溶剂的低分子量物质在内的溶质，在两性离子相和来自与二甲基氨基相相同供应商的硅胶上进行色谱分析。与硅胶相比，两性离子相是一种吸附性较弱的吸附剂，保留情况受所用强溶剂类型的影响较小。溶质在两性离子相上的保留值（log k'）与溶质从气相转移到水相的自由能高度相关。
