Ihara I, Kondo T, Kawakami M, Matsumoto T, Tsujitani M
Jpn J Antibiot. 1975 Feb;28(1):53-60.
The therapeutic potencies of colistin methanesulfonate (CLM) was assessed quantitatively in acute infection of mice with clinically isolated strains of Escherichia coli and Pseudomonas aeruginosa, and effect of different routes of administration was compared. There was no detectable difference in the therapeutic effect of CLM when intramuscular (im) or intravenous (iv) administration was initiated one hour after the infection. On the other hand, a significant difference in ED50 given by im and iv administrations was observed, indicating the superiority of iv administration, when the treatment started 4 to approximately hours after the infection. No difference in the therapeutic effect of polymyxin B (PMB) and tetracycline (TC) administered via either im or iv route was found even in the delayed administration. In contrast to PMB and TC, lower toxicity of CLM was determined when it was administered iv rather than im.
在小鼠感染临床分离的大肠杆菌和铜绿假单胞菌的急性感染模型中，对多粘菌素甲磺酸钠（CLM）的治疗效力进行了定量评估，并比较了不同给药途径的效果。感染后1小时开始肌肉注射（im）或静脉注射（iv）CLM，其治疗效果无明显差异。另一方面，当感染后4至约小时开始治疗时，观察到im和iv给药的半数有效剂量（ED50）有显著差异，表明iv给药更具优势。即使在延迟给药的情况下，通过im或iv途径给药的多粘菌素B（PMB）和四环素（TC）的治疗效果也没有差异。与PMB和TC相比，CLM静脉注射时的毒性低于肌肉注射。
