Wang Ju, Wang Lei, Wang Youde
Department of General Surgery, The First Hospital of Jilin University, Changchun 130021, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006 Feb;23(1):230-4.
Antisense oligonucleotides (ASODN) for therapy is a genetic technology which is based on the base-complementary principle. DNA or RNA sequence synthesized by biotechnology is transferred into the target cells to form mRNA-DNA or mRNA-RNA double strand for inhibiting the expression of target genes. In this way we can control and treat some diseases. The development of antisense oligonucleotides drugs has opened a new area of genetic pharmacology. This paper reviews its classifications, mechanics and its wide application in the treatment of viral infection, tumor and cardiovascular diseases. At the same time we pose the problems that need solving.
用于治疗的反义寡核苷酸（ASODN）是一种基于碱基互补原理的基因技术。通过生物技术合成的DNA或RNA序列被导入靶细胞，形成mRNA-DNA或mRNA-RNA双链，以抑制靶基因的表达。通过这种方式，我们可以控制和治疗一些疾病。反义寡核苷酸药物的发展开辟了基因药理学的新领域。本文综述了其分类、作用机制及其在治疗病毒感染、肿瘤和心血管疾病方面的广泛应用。同时，我们也提出了需要解决的问题。
