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基于深度剂量采用自适应正则化方法重建电子能谱。

Reconstruction of electron spectra from depth doses with adaptive regularization.

作者信息

Wei Jikun, Sandison George A, Chvetsov Alexei V

机构信息

School of Health Sciences, Purdue University, West Lafayette, Indiana 47907, USA.

出版信息

Med Phys. 2006 Feb;33(2):354-9. doi: 10.1118/1.2161404.

Abstract

Electron spectral reconstruction of medical accelerators from measured depth doses is a practical method for providing the input initial phase space distribution at the patient surface that is required by Monte Carlo treatment planning systems. The posed inverse problem of spectral reconstruction is ill conditioned and this may lead to nonphysical oscillations in the reconstructed spectra. Use of a variational method of solution with a regularization technique removes the oscillations but tends to smooth the sharp (deltalike) energy peak that is a common feature in electron spectra generated by medical accelerators. Because the sharp peak contains a large percentage of the electrons in the spectrum, an accurate estimate of the peak width, height and position is critical to the success of the technique for spectrum reconstruction with regularization. We propose use of an adaptive regularization term as a special form of the general Tichonov regularization function. The variational method with the adaptive regularization term is applied to reconstruct electron spectra for the 6, 9, and 18 MeV electron beams of a Varian Clinac 2100C accelerator and proves to be a very simple, effective and accurate approach. Results using this variational method with adaptive regularization almost perfectly reconstruct electron spectra from depth dose distributions.

摘要

从测量的深度剂量对医用加速器进行电子能谱重建,是一种为蒙特卡罗治疗计划系统提供患者表面所需输入初始相空间分布的实用方法。所提出的能谱重建反问题是病态的,这可能导致重建能谱中出现非物理振荡。使用带有正则化技术的变分法求解可消除振荡,但往往会使尖锐的(类似δ函数的)能量峰平滑,而这是医用加速器产生的电子能谱的一个常见特征。由于尖锐峰包含能谱中很大比例的电子,准确估计峰宽、峰高和峰位置对于正则化能谱重建技术的成功至关重要。我们建议使用自适应正则化项作为一般蒂洪诺夫正则化函数的一种特殊形式。带有自适应正则化项的变分法被应用于重建瓦里安Clinac 2100C加速器6、9和18 MeV电子束的电子能谱,并被证明是一种非常简单、有效且准确的方法。使用这种带有自适应正则化的变分法的结果几乎能从深度剂量分布完美重建电子能谱。

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