麻风病患者外观正常皮肤的组织病理学研究。
Histopathological study of apparently normal skin of patients with leprosy.
作者信息
El-Darouti Mohammad A, Hussein Soliman, Marzouk Salonaz A, Nabil Naglaa, Hunter Nahla S, Mahgoub Duaa, El-Eishi Nermine H, Abdel-Halim Mona R E
机构信息
Dermatology Department, Faculty of Medicine, Cairo University, Egypt.
出版信息
Int J Dermatol. 2006 Mar;45(3):292-6. doi: 10.1111/j.1365-4632.2005.02632.x.
BACKGROUND
Several clinical and laboratory observations point to the possible microscopical affection of normal-looking skin in leprosy.
OBJECTIVE
This study was carried out to verify the microscopical affection of apparently normal-looking skin in different types of leprosy.
PATIENTS AND METHODS
The study included 50 patients with different clinical types of leprosy. Biopsies from both skin lesions and normal-looking skin were obtained from each patient and examined for microscopical evidence of leprosy.
RESULTS
Microscopical affection of normal-looking skin was detected in 52% of our cases, with higher incidence of affection towards the lepromatous end of the disease.
CONCLUSION
Our findings underscore that the incidence of microscopical affection of normal-looking skin in leprosy is much higher on the lepromatous end of the spectrum of leprosy than on the tuberculoid end; during treatment, the leprosy granulomas may disappear from the normal skin before the clinical lesions. Moreover, the microscopic picture of indeterminate leprosy can be observed in the normal-looking skin of patients with tuberculoid leprosy or lepromatous leprosy, and this description appears not to be confined to the entity known as indeterminate leprosy.
背景
多项临床和实验室观察表明，麻风病中看似正常的皮肤可能存在微观病变。
目的
本研究旨在验证不同类型麻风病中看似正常的皮肤的微观病变情况。
患者与方法
该研究纳入了50例不同临床类型的麻风病患者。从每位患者的皮肤病变部位和看似正常的皮肤处获取活检样本，检查是否有麻风病的微观证据。
结果
在我们的病例中，52%检测到看似正常的皮肤存在微观病变，在疾病的瘤型阶段病变发生率更高。
结论
我们的研究结果强调，麻风病中看似正常的皮肤微观病变发生率在麻风病谱系的瘤型端比结核样型端高得多；在治疗过程中，麻风肉芽肿可能在临床病变之前从正常皮肤中消失。此外，在结核样型麻风或瘤型麻风患者看似正常的皮肤中可观察到未定类麻风的微观表现，且这种描述似乎并不局限于所谓的未定类麻风。
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