[环磷酸腺苷（cAMP）系统在大鼠非致死性分次γ射线照射后组织中鸟氨酸脱羧酶激活过程中的可能参与情况]
[The possible participation of the cAMP system in the activation of ornithine decarboxylase in rat tissues following nonlethal fractionated gamma-irradiation].
作者信息
Slozhenikina L V, Fialkovskaia L A, Ushakova T E, Kuzin A M
出版信息
Radiobiologiia. 1991 May-Jun;31(3):361-4.
PMID:1653439
Abstract
A study was made of the activity of adenylate cyclase and cAMP-phosphodiesterase in rat thymus and liver various time intervals following nonlethal fractionated gamma-irradiation (2 Gy three times at a week interval). There was a positive correlation between the activity of cAMP metabolism enzymes and the radiation modification of ornithine decarboxylase (ODC) observed before. It is suggested that cAMP system is involved in ODC activity regulation in the exposed tissue.
摘要
对非致死性分次γ射线照射（每周间隔一次，每次2 Gy，共三次）后不同时间间隔大鼠胸腺和肝脏中腺苷酸环化酶及cAMP磷酸二酯酶的活性进行了研究。之前观察到cAMP代谢酶的活性与鸟氨酸脱羧酶（ODC）的辐射修饰之间存在正相关。提示cAMP系统参与了受照射组织中ODC活性的调节。
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