Jani Alkesh, Wang Wei, Faubel Sarah, Falk Sandor, Ljubanovic Danica, Dursun Belda, Edelstein Charles L
Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
Transplantation. 2006 Mar 15;81(5):800-3. doi: 10.1097/01.tp.0000202750.57765.c2.
Uninephrectomy is associated with increased glomerular filtration rate in both the donated and the remaining contralateral kidney. The long-term effects of ischemic acute renal failure (ARF) following uninephrectomy are unknown. This study examined renal function, histology and proteinuria 52 weeks after an episode of reversible ischemic ARF. Ischemic ARF was induced in uninephrectomised mice by renal pedicle clamping. At 52 weeks inulin clearance (muL/min/g) was 7.2+/-0.2 in sham, 5.0+/-0.1 in uninephrectomy (P<0.01 vs. sham) and 3.9+/-0.1 in uninephrectomy + ischemia (P<0.01 vs. sham, P<0.05 vs. uninephrectomy). Thus, mice subjected to uninephrectomy alone demonstrated compensatory hyperfiltration following reduction in renal mass. This response was prevented by ischemic ARF. At 52 weeks there was no difference in urine protein/creatinine, mean arterial pressure or scores of glomerulosclerosis or interstitial fibrosis. In conclusion, ischemic ARF following uninephrectomy in mice impairs long-term renal function.
单侧肾切除与供体肾及对侧剩余肾的肾小球滤过率增加有关。单侧肾切除后缺血性急性肾衰竭（ARF）的长期影响尚不清楚。本研究在可逆性缺血性ARF发作52周后检测了肾功能、组织学和蛋白尿情况。通过肾蒂夹闭在单侧肾切除的小鼠中诱导缺血性ARF。在52周时，假手术组的菊粉清除率（μL/min/g）为7.2±0.2，单侧肾切除组为5.0±0.1（与假手术组相比，P<0.01），单侧肾切除+缺血组为3.9±0.1（与假手术组相比，P<0.01；与单侧肾切除组相比，P<0.05）。因此，仅接受单侧肾切除的小鼠在肾质量减少后表现出代偿性高滤过。这种反应被缺血性ARF所阻止。在52周时，尿蛋白/肌酐、平均动脉压或肾小球硬化或间质纤维化评分没有差异。总之，小鼠单侧肾切除后的缺血性ARF损害长期肾功能。
