Kerbl Reinhold, Urban Christian E, Zotter Heinz, Lackner Herwig, Sovinz Petra, Ambros Peter F
Department of Pediatrics and Adolescent Medicine, Medical University Graz, Graz, Austria.
Pediatr Blood Cancer. 2007 Dec;49(7):1012-4. doi: 10.1002/pbc.20828.
A follow-up study was performed for children with previous repeated positive results by neuroblastoma mass screening and negative clinical results (30 out of 439,128 children screened in Austria between 1991 and 2003, median follow-up 113 months). Four children had continuously elevated urine catecholamines for more than 6 months. One of these patients was diagnosed with pelvic neuroblastoma and multiple metastases 10 years after the first positive screening result. In the light of a 'wait and see' strategy for localized neuroblastomas, our observation suggests that these patients should be further observed even after normalization of urine catecholamines.
对先前神经母细胞瘤大规模筛查结果反复呈阳性但临床结果为阴性的儿童进行了一项随访研究（1991年至2003年在奥地利筛查的439,128名儿童中有30名，中位随访时间为113个月）。4名儿童尿儿茶酚胺持续升高超过6个月。其中1例患者在首次筛查结果呈阳性10年后被诊断为盆腔神经母细胞瘤并伴有多处转移。鉴于对局限性神经母细胞瘤采取“观察等待”策略，我们的观察结果表明，即使尿儿茶酚胺恢复正常，这些患者仍应进一步观察。
